The Disconnection Approach in organic chemistry is a strategic method for synthesizing complex molecules. It involves retrosynthetic analysis, breaking down a target molecule into simpler units called 'synthons'. Developed by Nobel laureate E.J. Corey, this approach revolutionized synthetic planning, emphasizing the importance of functional group interconversion, strategic bond disconnection, and the use of protecting groups. It contrasts traditional synthesis by working in reverse, from the final product to starting materials, streamlining the synthesis process.
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Retrosynthetic analysis is the process of envisioning a target molecule in reverse and breaking it down into simpler units known as 'synthons'
Definition
Strategic bonds are key functional groups and bonds suitable for disconnection in the Disconnection Approach
Role in Retrosynthetic Analysis
Strategic bonds guide the retrosynthetic thought process and help chemists trace a path back to readily available or easily synthesized starting materials
Functional group interconversion is the transformation of one functional group into another to facilitate synthesis in the Disconnection Approach
Synthetic equivalents are molecules that have similar reactivity and can be transformed into each other under certain conditions in the Disconnection Approach
Synthetic equivalents are matched with idealized fragments to aid in the systematic reassembly of simpler building blocks into the final product
Protecting groups are temporary modifications of functional groups used to prevent unwanted reactions and allow for selective reactions in other parts of the molecule
Protecting groups are employed in the Disconnection Approach to preserve stereochemical integrity and facilitate the construction of complex molecules
The incorporation of computational chemistry and artificial intelligence aids in predicting synthetic pathways and optimizing retrosynthetic plans in the Disconnection Approach
The integration of green chemistry principles emphasizes the need for sustainable and environmentally friendly practices in chemical synthesis in the Disconnection Approach
Challenges in the Disconnection Approach include considering synthons' reactivity, making non-obvious disconnections, and accounting for economic factors in synthetic planning
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The ______ Approach is a key strategy in organic chemistry for planning the synthesis of complex molecules.
Disconnection
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Nobel Prize in Chemistry 1990: Significance?
Awarded to E.J. Corey for pioneering the Disconnection Approach in organic synthesis.
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Disconnection Approach: Core Method?
Retrosynthetic analysis, breaking complex molecules into simpler precursors.
