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Diastereomers are stereoisomers with different configurations at one or more stereocenters, not mirror images of each other. They possess distinct physical properties such as melting points and solubilities, which are crucial in pharmaceuticals for drug efficacy and safety. Techniques like NMR and HPLC help in their identification and separation, impacting the sensory qualities of food and fragrances, and the kinetics of chemical reactions.
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Diastereomers are a type of stereoisomers that have different configurations at one or more stereocenters, and are important in fields such as medicine and food industry
Physical properties
Unlike enantiomers, diastereomers have different physical properties such as melting points, boiling points, and solubilities, allowing for their separation by laboratory techniques
Importance in drug design
The case of thalidomide highlights the significance of stereochemistry in drug design, as diastereomers can have different pharmacological activities and responses in the body
Diastereomers are found in substances like sugar, hormones, and drugs, and contribute to their distinct properties and effects
Techniques such as NMR and IR spectroscopy, as well as chromatography, are used to identify and separate diastereomers based on their physical and chemical properties
Physical properties
Diastereomers have different physical properties and can exhibit varied optical activities, making them distinguishable from enantiomers
Importance in chiral resolution
The ability to accurately identify and separate diastereomers from enantiomers is crucial for their practical application in fields like medicine and food industry
The physical properties of diastereomers, such as solubility and melting points, can significantly affect the kinetics and thermodynamics of chemical reactions, making them important in stereocontrolled syntheses
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Definition of Diastereomers
Stereoisomers with different configurations at one or more stereocenters, not mirror images.
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Physical Properties of Diastereomers
Have distinct melting points, boiling points, and solubilities, unlike enantiomers.
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Diastereomers in Pharmaceuticals
3D arrangement affects drug's pharmacological activity and body's response.
