Hebbian Theory: The Synaptic Basis of Learning and Memory

Hebbian theory, developed by Donald O. Hebb, explains how neurons that fire together wire together, forming the basis of learning and memory. This theory highlights the importance of synaptic plasticity, where repeated neural activity strengthens connections, leading to long-term potentiation (LTP). It also touches on neuroplasticity, the brain's ability to reorganize itself, which is vital for learning new skills and recovering from injuries. Empirical evidence, such as LTP and studies on London taxi drivers, supports Hebbian learning principles.

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Hebbian Theory: The Synaptic Basis of Learning

Hebbian theory, formulated by Canadian neuropsychologist Donald O. Hebb in 1949, provides a foundational understanding of the synaptic mechanisms underlying learning and memory. This theory is encapsulated in the adage "cells that fire together, wire together," suggesting that the simultaneous activation of neurons leads to the strengthening of their synaptic connections. Hebb proposed that associative learning results from the increased efficacy of synapses due to the repeated and persistent stimulation of one neuron by another. This synaptic plasticity is believed to be the cellular basis for learning and memory, as it enables the brain to encode associations between different stimuli and responses.
Three-dimensional neural network in the brain with interconnected neurons, dendrites and axon in shades of pink on a degrading blue background.

Synaptic Plasticity and Neuronal Connectivity

The biological underpinnings of Hebb's theory involve changes in synaptic strength between neurons. When a presynaptic neuron repeatedly and persistently stimulates a postsynaptic neuron, the synaptic connection between them is strengthened. This process, known as long-term potentiation (LTP), involves various molecular and structural changes, including the insertion of additional receptors into the synaptic membrane and the growth of new synaptic contacts. Hebb's concept of cell assemblies refers to networks of neurons that become functionally connected through such synaptic changes. These assemblies are thought to represent the neural basis of memory traces, as they encode specific patterns of information.

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1

According to the principle 'cells that fire together, wire together,' simultaneous activation of neurons may ______ their synaptic connections.

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strengthen

2

Define long-term potentiation (LTP).

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LTP is the persistent strengthening of synapses based on recent patterns of activity, involving molecular and structural changes.

3

What changes occur at the synaptic membrane during LTP?

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Additional receptors are inserted into the synaptic membrane, increasing synaptic efficiency.

4

What is a cell assembly in Hebb's theory?

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A network of neurons that become functionally connected through synaptic changes, representing the neural basis of memory traces.

5

The concept that neural pathways become stronger with repeated use is similar to how muscles get stronger through ______.

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exercise

6

Synaptic strengthening: definition and role in neuroplasticity

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Synaptic strengthening is the process of increasing synaptic efficacy, enhancing neural connections for improved cognitive function.

7

Synaptic pruning: purpose and impact on the brain

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Synaptic pruning is the elimination of weaker neural connections, streamlining brain pathways for more efficient operation.

8

Importance of lifelong learning and brain stimulation

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Continuous learning and mental challenges enhance neuroplasticity, aiding in memory formation and cognitive resilience.

9

The concept of ______ learning was supported by the discovery of ______, first observed by ______ in ______.

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Hebbian long-term potentiation (LTP) Terje Lømo 1966

10

Role of active engagement in Hebbian learning

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Active engagement reinforces neural connections, enhancing learning and memory retention.

11

Hebbian theory in brain injury rehabilitation

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Repetitive, task-specific exercises based on Hebbian theory aid synaptic changes, aiding recovery.

12

Neuroplasticity and cognitive resilience

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Lifelong learning and mental activity, underpinned by neuroplasticity, may delay neurodegenerative diseases.

13

Alternative frameworks to Hebb's theory include Piaget's ______ of cognitive development and Vygotsky's ______ perspective.

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stages sociocultural

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