The Zaitsev Rule, established by Alexander Zaitsev, is a principle in organic chemistry that predicts the major product in elimination reactions, favoring more substituted alkenes due to their stability. This rule is instrumental in the dehydration of alcohols and dehydrohalogenation of alkyl halides, aiding chemists in tailoring reaction conditions for desired outcomes. Understanding substitution, hyperconjugation, and the rule's application in complex mechanisms are key to its practical use in synthesis.
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1
The ______ Rule helps predict the primary product in organic chemistry's elimination reactions.
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2
Zaitsev Rule - General Principle
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3
Alkene Substitution Classification
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4
Hyperconjugation in Alkene Stability
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5
When dehydrating alcohols to create ______, the ______ Rule helps determine the predominant alkene.
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6
Identify alpha carbon in elimination reactions
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7
Determine beta carbons in Zaitsev Rule application
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8
Predict major product using Zaitsev Rule
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9
According to the ______, the first elimination from 2-bromopentane results in ______.
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10
When a second elimination happens, the ______ suggests that ______ will be the main product.
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11
Hoffmann's Rule - Predicted Major Product
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12
Markovnikov's Rule - Addition Reactions
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13
Factors Influencing Major Product Prediction
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14
In addition to the ______ Rule, chemists also consider ______ and ______ rules to gain deeper insights into reaction mechanisms in ______ chemistry.
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