The CoRR hypothesis, or 'co-location for redox regulation,' explains why certain genes are retained in eukaryotic cell organelles like mitochondria and chloroplasts. It suggests that the proximity of these genes to their gene products is crucial for regulating gene expression in response to the redox state. This concept supports the endosymbiotic theory and provides insight into the evolutionary conservation of organelle genomes, highlighting the importance of redox regulation in cellular energy dynamics.
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The CoRR hypothesis proposes that the physical proximity of genes to their gene products is essential for efficient regulation of gene expression in response to the redox state
Selective advantage of maintaining distinct genetic systems within organelles
The CoRR hypothesis has been refined to explain why certain genes are retained within organelles, despite the centralization of most genetic information within the nuclear genome
Endosymbiotic theory and genetic autonomy of organelles
The genetic autonomy of organelles supports the endosymbiotic theory, which suggests that these organelles originated from once free-living prokaryotes
Experimental data has shown that the redox state of organelles affects the transcription of genes involved in energy conversion processes, supporting the CoRR hypothesis
Chloroplasts are exclusive to plants and some protists, and are the sites of photosynthesis
Mitochondria are ubiquitous in eukaryotes and are responsible for cellular respiration and ATP production
Chloroplasts and mitochondria have their own DNA, supporting the endosymbiotic theory of their origin
The duplication of genetic material and synthesis of organelle-specific proteins by the nuclear genome presents an evolutionary puzzle
The CoRR hypothesis suggests that the proximity of certain genes to the biochemical environment of the organelle is necessary for efficient regulation of gene expression in response to the redox state
The CoRR hypothesis predicts that the primary subset of genes within organelles, involved in energy conversion processes, would eventually be lost if transferred to the nucleus due to the lack of selective pressure to maintain them
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CoRR hypothesis origin timeframe
Proposed in the 1990s
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CoRR hypothesis on gene retention rationale
Explains retention of certain genes in organelles for redox regulation efficiency
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CoRR hypothesis vs. nuclear genome centralization
Addresses why distinct genetic systems in organelles persist despite most genetic info in nucleus
