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The sodium-potassium pump, or Na+/K+-ATPase, is a crucial enzyme that regulates ion balance in animal cells. It actively transports Na+ and K+ ions using ATP, maintaining the electrochemical gradient necessary for nerve impulses and muscle contractions. Discovered by Jens Christian Skou, its various isoforms cater to the specific needs of different cell types, highlighting its importance in cellular biology and physiology.
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The sodium-potassium pump uses ATP to actively transport sodium and potassium ions against their concentration gradients, maintaining the cell's electrochemical gradient
The discovery of the sodium-potassium pump in 1957 revolutionized our understanding of cellular biology and its role in maintaining ion gradients
The sodium-potassium pump has multiple isoforms that are expressed in different tissues to meet their specific physiological demands
The sodium-potassium pump belongs to the P-type ATPase family, which is responsible for transporting ions across cell membranes against their concentration gradients
The sodium-potassium pump undergoes phosphorylation during the ATP hydrolysis cycle, inducing conformational changes necessary for ion movement
The sodium-potassium pump plays a crucial role in maintaining ionic balance and membrane potential, essential for cell viability and function
00
The ______-______ pump, also known as ______, is a vital enzyme found in the plasma membranes of ______ cells.
sodium-potassium
Na+/K+-ATPase
animal
01
This active transporter moves ______ and ______ ions across the cell membrane against their concentration gradients, utilizing ______ energy.
sodium (Na+)
potassium (K+)
ATP hydrolysis
02
Sodium-potassium pump ion exchange ratio
Transports 3 Na+ ions out, 2 K+ ions in per ATP molecule.
