Arenaviruses are enveloped viruses with a bisegmented RNA genome, transmitted to humans through rodents, causing diseases like Lassa fever. They utilize an ambisense coding strategy for replication. Understanding their transmission, clinical presentation, and management is crucial for public health, with research advancing potential treatments and vaccines.
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Arenaviruses have a distinctive spherical shape and are enveloped viruses
Ambisense coding strategy
Arenaviruses use an ambisense coding strategy to synthesize proteins in both directions, which is crucial for their replication and pathogenicity
The lipid bilayer of Arenaviruses contains embedded glycoproteins
Large (L) and Small (S) segments
The genome of Arenaviruses is composed of two single-stranded RNA segments, the Large (L) and Small (S) segments
Complex transcription mechanism
The ambisense coding strategy of Arenaviruses requires a complex transcription mechanism for their replication cycle
Arenaviruses are primarily transmitted to humans through contact with infected rodent hosts, particularly species in the Muridae family
Arenaviruses are zoonotic pathogens that are transmitted from their natural rodent reservoirs to humans
Although less common, human-to-human transmission of Arenaviruses can occur, particularly in healthcare settings
The management of Arenavirus infections involves supportive care
Antiviral drugs such as Ribavirin can be administered to treat Arenavirus infections
Rodent control
Prevention strategies for Arenaviruses include rodent control to reduce the risk of transmission
Public health education
Public health education is crucial in preventing the spread of Arenaviruses
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Infections with ______ can result in serious illnesses like Lassa fever and Argentine hemorrhagic fever, which can be fatal without quick and proper care.
arenaviruses
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Arenavirus L Segment Function
Encodes RNA-dependent RNA polymerase and matrix protein.
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Arenavirus S Segment Function
Encodes nucleoprotein and glycoprotein precursor.
