Aldosterone is a hormone essential for fluid and electrolyte balance, influencing blood pressure and acid-base homeostasis. Produced in the adrenal cortex, it's regulated by the RAAS system and affects kidney function. Imbalances such as hypoaldosteronism and hyperaldosteronism can lead to significant health issues, requiring careful management to maintain bodily equilibrium.
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Aldosterone is a hormone produced in the adrenal cortex's zona glomerulosa, located on top of the kidneys
Renin-Angiotensin-Aldosterone System (RAAS)
The RAAS is responsible for regulating aldosterone secretion in response to changes in blood volume, sodium concentration, and potassium levels
Aldosterone plays a crucial role in maintaining fluid and electrolyte balance in the body, primarily by promoting sodium reabsorption and potassium and hydrogen ion excretion in the kidneys
Aldosterone and cortisol are both steroid hormones produced in the adrenal cortex, but they have distinct physiological roles due to their different biosynthetic pathways and specific enzymes
While aldosterone is responsible for regulating fluid and electrolyte balance, cortisol plays a key role in the body's response to stress
Hypoaldosteronism, characterized by low levels of aldosterone, can be caused by primary adrenal insufficiency, genetic conditions, or certain medications, and can lead to symptoms such as fatigue, muscle weakness, and dehydration
If left untreated, hypoaldosteronism can lead to serious complications, but prompt diagnosis and management are crucial for alleviating symptoms and preventing an Addisonian crisis
Hyperaldosteronism, characterized by high levels of aldosterone, can be caused by an adrenal adenoma or other underlying conditions, and can lead to symptoms such as high blood pressure, muscle weakness, and edema
Identifying and treating the underlying cause is essential for managing hyperaldosteronism, which may involve adjusting medications, modifying diet, or surgical intervention
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Aldosterone function in body
Regulates fluid, electrolyte balance, stabilizes BP, ensures physiological adaptability.
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Aldosterone production location
Produced in adrenal cortex's zona glomerulosa, atop kidneys.
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Effect of angiotensin II on aldosterone
Stimulates aldosterone production, acts as vasoconstrictor.
