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The Baltimore Classification System, created by David Baltimore, categorizes viruses into seven classes based on genetic material and mRNA synthesis. It's crucial for understanding viral replication, guiding antiviral drug development, and managing infections. The system's insights into viral gene expression and host interactions are vital for microbiology advancements.
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The Baltimore Classification System was created by Nobel Prize-winning virologist David Baltimore to classify viruses based on their genetic material and mRNA synthesis
Class I - Double-stranded DNA viruses
Class I viruses use DNA-dependent DNA polymerase for replication
Class II - Single-stranded DNA viruses
Class II viruses rely on host cell enzymes for replication
Class III - Double-stranded RNA viruses
Class III viruses use RNA-dependent RNA polymerase for replication
Class IV - Positive-sense single-stranded RNA viruses
Class IV viruses serve directly as mRNA
Class V - Negative-sense single-stranded RNA viruses
Class V viruses must first be transcribed into a positive-sense mRNA
Class VI - Retroviruses
Class VI viruses reverse transcribe their RNA into DNA
Class VII - Reverse-transcribing viruses with a double-stranded DNA intermediate
Class VII viruses replicate through a reverse-transcribed RNA intermediate
The Baltimore Classification System is used to develop antiviral therapies and manage viral infections by identifying the replication mechanism of a virus
The Baltimore Classification System allows for the study of viral gene expression, adaptability, and evolution, which are crucial for genetic research and the development of diagnostic tools and therapeutics
The Baltimore Classification System focuses on the biochemical processes involved in viral mRNA synthesis, providing insights into the molecular interactions between viruses and their hosts
The Baltimore Classification System complements other classification systems by providing a systematic approach to categorize viruses based on their mechanisms of gene expression and replication
The Baltimore Classification System informs the development of antiviral drugs by identifying specific stages of the viral life cycle to target
HIV Treatment
The Baltimore Classification System has influenced the development of antiretroviral therapy for HIV, a Class VI virus
Treatment of Other Viruses
The Baltimore Classification System has practical applications in the treatment of viruses such as Herpes simplex virus (Class I), Parvovirus B19 (Class II), and Rotavirus (Class III)
00
In the Baltimore Classification, Class I includes ______-stranded DNA viruses, while Class VII contains ______-transcribing viruses with a ______-stranded DNA intermediate.
double
reverse
double
01
Class I virus replication enzyme
Uses DNA-dependent DNA polymerase.
02
Class III virus genome type
Has double-stranded RNA genome.
