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Overview of the Innate Immune System

The innate immune system is the body's initial defense against pathogens, featuring barriers like skin, cellular defenses such as phagocytes, and molecular responses like cytokines. It includes an inflammatory response to isolate foreign substances and utilizes white blood cells for protection. Pathogens have evolved to evade this system, highlighting the need for advanced research in immunology.

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1

Innate vs. Adaptive Immune System

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Innate immune system provides immediate defense, lacks memory. Adaptive immune system is slower, specific, and has memory.

2

Role of Innate Immunity in Vertebrates

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In vertebrates, innate immunity acts as first response and works alongside adaptive immunity for enhanced protection.

3

Innate Immunity in Invertebrates and Plants

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In invertebrates, plants, fungi, and prokaryotes, innate immunity is the exclusive defense mechanism against pathogens.

4

The ______ and mucosal surfaces are the body's initial defense in the innate immune system.

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skin

5

Mechanical processes like the flushing action of ______ and ______ help reinforce the body's anatomical barriers.

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tears saliva

6

The stomach's ______ environment and antimicrobial peptides are chemical defenses in the innate immune system.

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acidic

7

Normal microbiota in the gut compete with potential pathogens for ______ and ______, providing biological protection.

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resources space

8

Inflammation triggers: What initiates the inflammatory response?

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Inflammation is initiated by tissue injury from bacteria, trauma, toxins, heat, or other harmful events.

9

Inflammatory response: How do leukocytes react at the injury site?

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Leukocytes are drawn to the injury site, where they engulf and neutralize foreign substances.

10

In the blood, complement proteins are normally ______, but they activate upon encountering ______.

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inactive pathogens

11

Activation of the complement system results in a series of reactions that ______ phagocytosis and attract ______ cells.

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enhance inflammatory

12

The complement system can form ______ attack complexes to directly destroy ______.

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membrane pathogens

13

There are multiple pathways to activate the complement system: ______, ______, and ______ pathways.

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classical alternative lectin

14

Primary function of neutrophils

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Neutrophils provide rapid response to infection, engulfing and destroying pathogens.

15

Role of lymphocytes in immune response

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Lymphocytes include NK cells and T- and B-cells, crucial for targeted immune response and memory.

16

Monocytes differentiation and purpose

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Monocytes differentiate into macrophages and dendritic cells, key for phagocytosis and antigen presentation.

17

______ cells release histamine during infections and contribute to ______ reactions.

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Mast allergic

18

______ are cells that consume and break down cellular waste and ______.

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Macrophages pathogens

19

The most numerous white blood cells that rapidly respond to infections are called ______.

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neutrophils

20

______ cells assist in the immune response by presenting antigens to T cells, bridging ______ and ______ immune systems.

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Dendritic innate adaptive

21

In the body's defense system, each type of cell, such as mast cells, macrophages, and neutrophils, has ______ roles.

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unique

22

Pathogen surface protein alteration purpose

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Avoids immune recognition by changing proteins to escape detection.

23

Pathogen survival in host cells significance

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Shields from immune system, evading components like antibodies and complement proteins.

24

Invertebrates defend themselves using physical barriers, ______ cells, and ______ peptides.

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phagocytic antimicrobial

25

Plants possess a complex ______ immunity system that can detect and respond to ______ attacks.

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innate pathogen

26

Studying the innate immune systems across various species helps us understand the ______ of immune defense mechanisms.

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evolution

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Overview of the Innate Immune System

The innate immune system, also known as the nonspecific immune system, is the first line of defense against pathogens in all multicellular organisms. In vertebrates, it works in concert with the adaptive immune system, while it is the sole defense mechanism in invertebrates, plants, fungi, and prokaryotes. This system includes physical barriers like skin and mucous membranes, cellular defenses such as phagocytes and natural killer cells, and molecular responses like the complement system and cytokines. It is characterized by its rapid response and ability to recognize common molecular patterns on pathogens, but it does not confer long-lasting immunity to the host.
Close-up of human skin with details of the epidermis, pigmentation variations and cross section of its stratifications.

Anatomical Barriers and Defense Mechanisms

The body's anatomical barriers, primarily the skin and mucosal surfaces, serve as the first line of defense in the innate immune system. These barriers are reinforced by mechanical processes such as the flushing action of tears and saliva, and chemical defenses including the acidic environment of the stomach and antimicrobial peptides. Biological mechanisms, such as the normal microbiota that colonize the gut and other sites, also play a protective role by outcompeting potential pathogens for resources and space.

Inflammatory Response as a Defense Strategy

Inflammation is a hallmark of the innate immune response, occurring when tissues are injured by bacteria, trauma, toxins, heat, or any other cause. The damaged cells release chemicals that cause blood vessels to leak fluid into the tissues, causing swelling. This helps isolate the foreign substance from further contact with body tissues. The inflammatory response also draws leukocytes to the site of injury, where they engulf and destroy foreign substances.

The Complement System in Pathogen Clearance

The complement system is a group of proteins that play a crucial role in the innate immune response. These proteins circulate in the blood in an inactive form and are activated in the presence of pathogens, leading to a cascade of reactions that enhance phagocytosis, directly kill pathogens by forming membrane attack complexes, and recruit inflammatory cells to the site of infection. The complement system can be activated through several pathways, including the classical, alternative, and lectin pathways, each initiated by different stimuli.

Role of White Blood Cells in Innate Immunity

White blood cells, or leukocytes, are essential components of the innate immune system. These cells are involved in protecting the body against both infectious disease and foreign invaders. The major types of leukocytes include neutrophils, eosinophils, basophils, lymphocytes (which include natural killer cells and certain types of T- and B-cells), and monocytes (which differentiate into macrophages and dendritic cells). Each type of leukocyte has a distinct role, with some providing a first line of defense against pathogens and others playing roles in inflammation or allergic responses.

Specialized Innate Immune Cells and Their Functions

Specialized cells of the innate immune system include mast cells, which release histamine and other mediators in response to infection and play a role in allergic reactions; macrophages, which engulf and digest cellular debris and pathogens; neutrophils, which are the most abundant type of white blood cells and are the first to arrive at the site of infection; and dendritic cells, which present antigens to T cells, thus linking the innate and adaptive immune systems. Each of these cell types has unique functions and plays a critical role in the body's defense mechanisms.

Immune Evasion by Pathogens

Pathogens have developed sophisticated mechanisms to evade the innate immune system. These include altering their surface proteins to avoid recognition, producing substances that inhibit complement activation, and secreting enzymes that degrade antibodies. Some pathogens can also survive within host cells, where they are protected from many components of the immune system. Understanding these evasion strategies is crucial for the development of new treatments and vaccines.

Innate Immunity Beyond Vertebrates

Innate immunity is not exclusive to vertebrates; it is an ancient and universal form of defense found in all classes of life, including invertebrates, plants, and microorganisms. Invertebrates, for example, rely on a combination of physical barriers, phagocytic cells, and antimicrobial peptides for defense. Plants have a sophisticated system of innate immunity that includes physical barriers, chemical responses, and a unique set of immune cells that can recognize pathogen attack and trigger defense responses. Understanding the similarities and differences in innate immune systems across different organisms provides insight into the evolution of immune defense mechanisms.