;
Feedback
What do you think about us?
Your name
Your email
Message
Exploring the role of post-transcriptional regulation in gene expression, this overview highlights the mechanisms that govern RNA stability, processing, and localization. RNA-binding proteins and their motifs play a key role in alternative splicing, mRNA stability, and nuclear export, which are essential for proper cellular function and have implications in diseases like cancer and neurodegenerative disorders.
Show More
5' Cap of mRNA
The 5' cap of mRNA protects the transcript from degradation and is essential for translation initiation
RNA Splicing
RNA splicing removes non-coding sequences from pre-mRNA, resulting in a mature mRNA for translation
Poly(A) Tail
The addition of a poly(A) tail at the 3' end of RNA protects it from degradation and can influence translation efficiency
mRNA Stability
mRNA stability is crucial for regulating gene expression levels and can be influenced by factors such as the poly(A) tail
Nuclear Export
The nuclear export system is responsible for transporting mature mRNA from the nucleus to the cytoplasm, preventing translation of defective transcripts
RNA-Binding Proteins and Alternative Splicing
RNA-binding proteins can alter alternative splicing patterns, increasing the diversity of proteins produced from a single gene
RNA-Binding Proteins and Selective Degradation
RNA-binding proteins oversee the selective degradation of RNA in the nucleus, ensuring only high-quality transcripts are translated
RNA-Binding Proteins and Localization
RNA-binding proteins can localize RNA to specific subcellular compartments, such as P-bodies, for storage or degradation
Aberrations in post-transcriptional regulation can contribute to the misexpression of genes and the onset of diseases such as cancer and neurodegenerative disorders
A thorough understanding of post-transcriptional mechanisms can aid in the development of targeted therapies by manipulating specific components of RNA regulation
00
The stage between ______ and ______ is managed by post-transcriptional regulation, which is vital for gene function across various human tissues.
transcription
translation
01
Post-transcriptional regulation plays a role in diseases such as ______ and ______ disorders.
cancer
neurodegenerative
02
Function of 5' mRNA cap
Protects mRNA from degradation; essential for translation initiation.
