Transcription attenuation in prokaryotes is a gene regulation mechanism that adjusts protein production by terminating transcription. It relies on RNA structures and can be intrinsic or Rho-dependent. Unlike prokaryotes, eukaryotes use miRNAs and RISC for gene regulation due to their compartmentalized cellular structure, which separates transcription and translation processes.
Show More
Transcription attenuation is a mechanism of gene regulation in prokaryotes that involves the premature termination of transcription
Intrinsic termination
Intrinsic termination is a type of transcription attenuation that involves the formation of secondary RNA structures, such as hairpin loops and poly-uracil tracts
Factor-dependent termination
Factor-dependent termination is a type of transcription attenuation that involves the Rho protein and specific RNA sequences
Transcription attenuation allows bacteria to rapidly adapt to changing environments by conserving resources and modulating metabolic pathways
The physical separation of transcription and translation in eukaryotic cells prevents the direct coupling necessary for transcription attenuation
Eukaryotic cells have evolved alternative regulatory strategies, such as post-transcriptional and post-translational modifications, to control gene expression
MicroRNAs play a key role in controlling gene expression in eukaryotic cells by binding to complementary sequences within the 3' untranslated regions of target mRNAs
MicroRNAs function through the RNA-induced silencing complex to inhibit translation or degrade target mRNAs
00
______ attenuation is a unique form of ______ control found only in ______, affecting gene expression during transcription.
Transcription
gene
prokaryotes
01
The process involves early halting of transcription, which decreases the ______ of certain ______.
production
proteins
02
Secondary RNA structures can interfere with RNA polymerase movement along the ______ template.
DNA
