Mitochondrial disorders are diseases caused by the dysfunction of mitochondria, crucial for ATP production and energy supply. These conditions can lead to symptoms like muscle weakness, neurological deficits, and can be linked to diabetes and neurodegenerative diseases. Understanding the genetic mutations in both mitochondrial and nuclear DNA is key to grasping the varied clinical manifestations and inheritance patterns of these disorders.
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1
Primary function of mitochondria in cells
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2
Common systems affected by mitochondrial disorders
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3
Examples of mitochondrial disorders
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4
These disorders may also be linked with other conditions such as ______ and neurodegenerative diseases like ______ and ______.
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5
The manifestation of mitochondrial disorders depends on the ______ causing the condition, the ______ of affected mitochondria, and the ______ needs of the tissues involved.
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6
Mitochondrial disorders are also connected with certain ______ disorders.
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7
Inheritance pattern of mtDNA
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8
Impact of heteroplasmy on disease
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9
Mutations in ______ DNA can significantly impact ______ function, resulting in a variety of ______ phenotypes.
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10
Consequence of impaired mitochondrial function in diabetes
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11
Impact of mitochondrial dysfunction on cellular signaling
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12
Mitochondria's role in cellular health
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13
The body's capacity to create and accumulate ______ is indicative of its energy production ability, especially in high-demand ______ like the brain and muscles.
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14
Grasping the link between ______ and ______ metabolism is vital for understanding how mitochondrial disorders affect the body's energy balance.
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