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Maternal Inheritance of Mitochondrial DNA in Eukaryotes

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Exploring the maternal inheritance of mitochondrial DNA (mtDNA) in eukaryotes, this overview delves into the biological mechanisms behind it, the potential for biparental inheritance, and the use of mtDNA in tracing matrilineal ancestry. It also discusses the mitochondrial bottleneck's role in genetic diversity, rare cases of paternal mtDNA transmission, and the groundbreaking mitochondrial replacement therapy for disease prevention.

Maternal Inheritance of Mitochondrial DNA in Eukaryotes

Mitochondrial DNA (mtDNA) is inherited almost exclusively from the mother in most eukaryotic organisms, including animals, plants, and fungi. This maternal inheritance is due to several biological mechanisms. The egg cell contributes a vastly greater number of mitochondria compared to the sperm—typically around 100,000 to 200,000 versus just a few dozen. Additionally, mechanisms exist to actively degrade or exclude the mitochondria from the sperm. For example, in many species, sperm mitochondria are marked for degradation by ubiquitin, and the tail of the sperm, where most of the mitochondria are located, does not enter the egg during fertilization. Consequently, mtDNA is typically passed down from the mother, following a uniparental inheritance pattern.
Central human ovum surrounded by sperm cells with silver heads and wavy tails on a light blue to lavender gradient background.

Reevaluation of mtDNA Inheritance Patterns

The traditional model of strict maternal mtDNA inheritance has been questioned by studies, including one from 2018, which suggested the possibility of biparental inheritance of mtDNA in humans, leading to mtDNA heteroplasmy. This claim has been met with skepticism, and further research has indicated that the supposed paternal mtDNA might actually be nuclear DNA sequences that resemble mtDNA. The consensus remains that maternal inheritance is the predominant mode of mtDNA transmission, but the existence of rare exceptions in certain contexts and species is acknowledged.

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00

In most ______ organisms, mtDNA is inherited almost exclusively from the ______.

eukaryotic

mother

01

The egg cell has significantly more mitochondria, about ______ to ______, compared to the sperm's few dozen.

100,000

200,000

02

Sperm mitochondria are often tagged for destruction by ______, and during fertilization, the sperm's ______ usually doesn't merge with the egg.

ubiquitin

tail

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